Table 1.
Summary of the 76 selected SNPs in 27 genes
| Gene | Chr | SNP id | Alleles a | Chr position | Location | MAF controls b | HWE controls c |
|---|---|---|---|---|---|---|---|
| CAT | 11 | rs1049982 | C/T | 34417117 | 5´UTR | 0.355 | 0.66 |
| rs475043 | A/G | 34450377 | downstream | 0.334 | 0.73 | ||
| rs511895 | A/G | 34444305 | intronic | 0.332 | 0.73 | ||
| rs7104301 | A/G | 34450214 | downstream | 0.308 | 0.18 | ||
| rs769214 | A/G | 34416293 | promoter | 0.349 | 0.61 | ||
| CYBB | X | rs5964125 | A/G | 37543395 | intronic | 0.150 | 0.37 |
| rs5964151 | G/T | 37555673 | 3´UTR | 0.149 | 0.45 | ||
| GCLC | 6 | rs1014852 | A/T | 53478711 | intronic | 0.057 | 0.27 |
| rs11415624 | -/A | 53470407 | 3´UTR | 0.315 | 0.08 | ||
| rs3736729 | A/C | 53487364 | intronic | 0.462 | 0.36 | ||
| rs4140528 | C/T | 53469648 | downstream | 0.265 | 0.62 | ||
| GCLM | 1 | rs7515191 | A/G | 94139685 | intronic | 0.368 | 0.57 |
| rs7549683 | G/T | 94126037 | 3´UTR | 0.367 | 0.46 | ||
| GNAS | 20 | rs4812042 | A/G | 56895310 | intronic | 0.340 | 0.20 |
| rs7121 | C/T | 56912202 | coding (synonymous) | 0.449 | 0.70 | ||
| rs919196 | C/T | 56917480 | intronic | 0.195 | 0.63 | ||
| GPX6 | 6 | rs406113 | A/C | 28591461 | coding (missense) | 0.310 | 0.08 |
| rs974334 | C/G | 28582197 | intronic | 0.157 | 0.31 | ||
| GSR | 8 | rs1002149 | G/T | 30705280 | promoter | 0.152 | 0.65 |
| rs2551715 | A/G | 30666178 | intronic | 0.375 | 1.00 | ||
| rs2911678 | A/T | 30659513 | intronic | 0.189 | 0.53 | ||
| rs8190996 | C/T | 30673548 | intronic | 0.437 | 0.81 | ||
| GSS | 20 | rs13041792 | A/G | 33008716 | promoter | 0.202 | 0.63 |
| rs2273684 | G/T | 32993427 | intronic | 0.438 | 0.07 | ||
| rs725521 | C/T | 32979732 | downstream | 0.456 | 0.02 | ||
| M6PR | 12 | rs1805754 | A/C | 8994515 | promoter | 0.236 | 0.16 |
| rs933462 | G/T | 8994932 | promoter | 0.419 | 0.94 | ||
| MSRB2 | 10 | rs11013291 | C/T | 23440197 | intronic | 0.394 | 0.69 |
| NCF2 | 1 | rs2274064 | C/T | 181809010 | coding (missense) | 0.444 | 0.27 |
| rs2274065 | A/C | 181826327 | 5´UTR | 0.067 | 0.22 | ||
| rs2296164 | C/T | 181801558 | intronic | 0.452 | 0.24 | ||
| NCF4 | 22 | rs2072712 | C/T | 35601748 | coding (synonymous) | 0.089 | 0.05 |
| NOS1 | 12 | rs570234 | A/C | 116255365 | intronic | 0.385 | 0.80 |
| rs576881 | A/G | 116257218 | intronic | 0.372 | 0.62 | ||
| rs816296 | A/C | 116255127 | intronic | 0.189 | 0.17 | ||
| NOS2A | 17 | rs2779248 | C/T | 23151959 | upstream | 0.362 | 0.11 |
| rs3729508 | A/G | 23133157 | intronic | 0.447 | 0.58 | ||
| NOX1 | X | rs4827881 | A/C | 100016329 | upstream | 0.223 | 0.05 |
| rs5921682 | A/G | 100017093 | upstream | 0.459 | 0.88 | ||
| NOX3 | 6 | rs231954 | C/T | 155791727 | coding (synonymous) | 0.442 | 0.02 |
| rs3749930 | G/T | 155802938 | coding (missense) | 0.037 | 0.24 | ||
| NOX4 | 11 | rs490934 | C/G | 88863264 | intronic | 0.056 | 1.00 |
| NOX5 | 15 | rs2036343 | A/C | 67092815 | promoter | 0.048 | 0.19 |
| rs34990910 | A/G | 67118435 | intronic | 0.027 | 0.38 | ||
| OGG1 | 3 | rs1052133 | C/G | 9773773 | coding (missense) | 0.213 | 0.87 |
| SOD1 | 21 | rs17881274 | C/T | 31953051 | upstream | 0.039 | 0.07 |
| SOD2 | 6 | rs2842980 | A/T | 160020106 | downstream | 0.219 | 0.50 |
| rs2855116 | G/T | 160026115 | intronic | 0.454 | 0.12 | ||
| rs8031 | A/T | 160020630 | intronic | 0.459 | 0.35 | ||
| SOD3 | 4 | rs2284659 | G/T | 24403895 | promoter | 0.371 | 0.25 |
| TXN | 9 | rs2301241 | C/T | 112059329 | promoter | 0.514 | 0.25 |
| rs4135168 | A/G | 112056706 | intronic | 0.222 | 0.82 | ||
| rs4135179 | A/G | 112055821 | intronic | 0.156 | 0.24 | ||
| rs4135225 | C/T | 112046512 | intronic | 0.390 | 0.29 | ||
| TXN2 | 22 | rs2281082 | G/T | 35202696 | intronic | 0.170 | 0.41 |
| rs5756208 | A/T | 35207988 | promoter | 0.179 | 0.51 | ||
| TXNRD1 | 12 | rs10861201 | A/C | 103243089 | intronic | 0.259 | 0.31 |
| rs4077561 | C/T | 103204498 | promoter | 0.387 | 0.46 | ||
| rs4964287 | C/T | 103233689 | coding (synonymous) | 0.320 | 0.93 | ||
| rs4964778 | C/G | 103210194 | intronic | 0.184 | 0.61 | ||
| rs4964779 | C/T | 103218991 | intronic | 0.062 | 0.31 | ||
| rs5018287 | A/G | 103231281 | intronic | 0.419 | 0.88 | ||
| TXNRD2 | 22 | rs737866 | A/G | 18310109 | intronic | 0.293 | 0.77 |
| XDH | 2 | rs10175754 | C/T | 31475102 | intronic | 0.153 | 0.65 |
| rs10187719 | C/T | 31453650 | intronic | 0.311 | 0.78 | ||
| rs1346644 | C/G | 31479549 | intronic | 0.150 | 0.55 | ||
| rs1429374 | A/G | 31425902 | intronic | 0.338 | 0.10 | ||
| rs17011353 | C/T | 31441941 | intronic | 0.028 | 0.01 | ||
| rs17011368 | C/T | 31444421 | coding (missense) | 0.044 | 0.54 | ||
| rs17323225 | C/T | 31446769 | coding (missense) | 0.029 | 1.00 | ||
| rs1884725 | A/G | 31425290 | coding (synonymous) | 0.234 | 0.20 | ||
| rs206801 | C/T | 31482250 | intronic | 0.050 | 1.00 | ||
| rs206812 | A/G | 31491373 | promoter | 0.486 | 0.54 | ||
| rs2073316 | A/G | 31464533 | intronic | 0.427 | 0.69 | ||
| rs207454 | A/C | 31421136 | intronic | 0.087 | 0.81 | ||
| rs761926 | C/G | 31444289 | intronic | 0.300 | 0.72 |
Chr – chromosome; MAF – Minor Allele Frequency; HWE – Hardy Weinberg Equilibrium. amajority allele are in bold; bpolymorphisms with MAF <5% are excluded for further analysis; cpolymorphisms with p-values <0.05 are not in HWE and they are excluded for further analysis. The information about MAF and HWE are referent to the Set 1.
CAT: catalase; CYBB: cytochrome b-245, beta polypeptide; GCLC: glutamate-cysteine ligase, catalytic subunit; GCLM: glutamate-cysteine ligase, modifier subunit; GNAS: GNAS complex locus; GPX6: glutathione peroxidase 6; GSR: glutathione reductase; GSS: glutathione synthetase; M6PR: mannose-6-phosphate receptor; MSRB2: methionine sulfoxide reductase B2; NCF2: neutrophil cytosolic factor 2; NCF4: neutrophil cytosolic factor 4; NOS1: nitric oxide synthase 1; NOS2A: nitric oxide synthase 2; NOX1: NADPH oxidase 1; NOX3: NADPH oxidase 3; NOX4: NADPH oxidase 4; NOX5: NADPH oxidase 5; OGG1: 8-oxoguanine DNA glycosylase; SOD1: superoxide dismutase 1; SOD2: superoxide dismutase 2; SOD3: superoxide dismutase 3; TXN: thioredoxin; TXN2: thioredoxin 2; TXNRD1: thioredoxin reductase 1; TXNRD2: thioredoxin reductase 2; XDH: xanthine dehydrogenase.