Table 4.

Summary of Multi-factor Dimensionality (MDR) results

Model	Training accuracy	Testing accuracy	OR(95%CI)	p-value	CVC*
X2	0.5215	0.5093	1.18 (0.93-1.51)	0.1797	8/10
X2 – X5	0.5319	0.5199	1.30 (1.01-1.66)	0.041	8/10
X2 – X5 – X6	0.5353	0.5210	1.82 (1.28-2.58)	0.0007	7/10
X2 – X3 – X5 – X6	0.5371	0.5267	1.75 (1.26-2.44)	0.0008	10/ 10

The polymorphisms rs406113, rs974334, rs1052133 and rs2284659 showing the highest statistical significance in the combinatorial set1 + set 2 were chosen for gene-gene interaction analysis. *CVC, cross-validation consistency. Testing accuracy, p-value and CVC significant were highlighted in bold.

X2 = rs406113 (GPX6), X3 = rs974334 (GPX6), X5 = rs1052133 (OGG1), X6 = rs2284659 (SOD3).