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. Author manuscript; available in PMC: 2014 Dec 2.
Published in final edited form as: Annu Rev Genet. 2010;44:419–444. doi: 10.1146/annurev-genet-102209-163432

Figure 2.

Figure 2

Integration of the circadian transcriptome with other high-throughput levels of data. Circadian expression information can be integrated with multiple layers. (a) Expression levels of RNA transcripts are collected at multiple time points throughout a circadian cycle. (b) This circadian transcriptome can be integrated with genomics, protein pathway networks, information on tissue specificity, and phenotypic information. (c) By combining these multiple layers of global data, timing of molecular events, such as cis-element regulation and metabolic coordination, can be developed. The ultimate goal of these network-analysis approaches is to understand the regulatory mechanisms by which an organism’s internal circadian clock is able to temporally regulate biological processes.