Table 2. SNP Frequency and htSNPs in the HbAA and HbSS groups.

					Frequency
No.	ID	Position	SNP	Associated Allele	HbAA (%)	HbSS (%)	HbAA htSNP	HbSS htSNP	β-Locus Region
2	rs7119142	1580	T/C	C	36.2	76.2	√		HS4
3	rs34272388	7573	T/C	C	5.4	57.1		√	HS2
4	7579	7579	C/G	G	5.4	57.1
8	rs7119428	8580	A/C	C	5.2	57.1	√
14	rs7946623	12346	T/C	C	12.1	57.1
17	rs11036571	15024	C/A	A	8.9	25.6		√	HS1
18	rs7479652	17554	G/A	A	36.2	62.2	√	√	ε-globin
20	rs3759069	18831	C/T	C	32.8	59.5	√	√
21	rs3759071	19130	T/C	T	31	46.4
23	rs4910740	23370	T/C	T	44.8	25.6	√	√
24	rs10160271	25990	C/T	C	13.8	6	√	√
27	rs11820733	29227	C/T	T	16.7	46.4	√	√
29	rs10128653	33028	T/G	G	5.2	26.2	√	√	Gγ-globin
30	rs2855121	33198	A/G	A	15.5	7.1	√	√
31	rs2855122	33253	G/A	G	41.4	20.7	√	√
43	rs11827654	37975	C/T	T	24.1	58.3		√	Aγ-globin
44	rs2855039	38826	A/G	A	15.5	7.1	√
46	*rs6578593	40688	G/T	T	31	36.9	√
52	rs2071348	46334	A/C	C	17.2	7.1	√	√	ψβ-globin
53	rs11036415	47670	G/T	T	14.3	59.5	√	√
54	rs10488677	48982	C/A	A	15.5	6		√
73	rs334	62206	A/T	A	100	0			β-globin
83	*rs7480526	62705	G/T	G	37.9	33.3	√

The allele frequency for 23SNPs including some htSNPs (√) for the HbAA and HbSS groups are summarized. SNP selection criteria are described in the text. The β^S SNP (rs334) is indicated in bold letters. The column labeled “Variation” refers to wild-type/polymorphic nucleotide. The frequency was calculated for the associated allele. The “*“ indicates SNPs showing similar allele frequencies for both group. The nucleotide positions were located using the HBB record U01317; SNP distribution across the β-globin locus is indicated. Abbreviations: HS, hypersensitive site.