Figure 5.

GAS pretreatment inhibited Aβ _1–42-induced increase in firing rate of EC neurons in a concentration-dependent manner. (a) Representative traces show that pretreatment with 10 mM GAS (lower) prevented the Aβ _1–42-induced increase in firing rate of EC neurons, whereas saline (upper) had no obvious effect. (b) Time-response curves of Aβ _1–42-induced changes of firing rate in EC neurons, pretreated with saline or 10 mM GAS (^* P < 0.05, ^** P < 0.01 versus baseline values (500 s before saline or GAS injection)). (c) Concentration-dependent inhibitory effects of GAS on Aβ _1–42-induced firing rate changes (^# P < 0.05, ^## P < 0.01 versus saline alone group, ^& P < 0.05, ^&& P < 0.01 versus saline plus Aβ _1–42 group, ^* P < 0.05, ^** P < 0.01).