Table 3.

Multivariate cox regression model for OS in curative-intent (M0-stage) patients (n=43)

Variable	Comparison	Subject group1	Hazard ratio	95%-CI	P
Gender	Male vs. Female	Male	1.7	.7 - 4.9	.24
T-stage	T1-2 vs. T3-4	T3-T4	1.5	.3 - 7.3	.44
Weight loss	yes vs. no	yes	1.2	.4 - 3.5	.81
N-stage	N0-1 vs. N2-3	N0-1	.1	.03 - .5	.006
OPN (t1 to t2) 2	Decrease/Stable	Increase	3.6	1.6 - 8	.002

¹focused variable category with significantly increased (gender, T-stage, weight loss, OPN) or decreased (N-stage) hazard ratio.

²relative OPN level changes from t1 to t2 measuring time point; increase (+10% rise), decrease (-10% fall), stable (between +10% rise and -10% fall).