. Author manuscript; available in PMC: 2014 Dec 2.

Published in final edited form as: Mol Psychiatry. 2011 May 24;16(12):1159–1168. doi: 10.1038/mp.2011.58

Table 1.

miRNAs responsive to drugs of abuse that have also been associated with neuropsychiatric disorders

miRNA	Targeted gene(s)	Biological function(s)	Associated diseases
mir-124	REST⁵³ CREB⁵⁵ BDNF⁷⁹	Neuronal identity⁵³ 5-HT-induced learning⁵⁵ Plasticity⁷⁹	Cocaine addiction,⁷⁹ Alzheimer’s disease¹⁷
miR-132	P250GAP³⁹	Neurogenesis³⁹	Cocaine addiction,⁶⁸ Huntington’s disease¹⁷
miR-181b	VSNL1⁹⁵ GLIA1⁹⁵	Intracellular signaling⁹⁵ Neurotransmission⁹⁵	Nicotine dependence,²² schizophrenia⁹⁵
miR-30a-5p miR-29c	BDNF⁸²	Plasticity
miR-125b	Lin-28¹⁷ NR2A⁴³	Neurogenesis¹⁷ Neurotransmission/plasticity⁴³	Nicotine dependence,²² Alzheimer’s disease¹⁷
miR-93 miR-328	VEGF¹¹² BACE1¹⁰³	Cellular signaling¹¹² Axon guidance, potentiation¹¹³	ND,²² Alzheimer’s disease,¹⁷ schizophrenia¹¹³

Abbreviations: miRNAs, microRNAs; ND, nicotine dependence.