Table 1.

Allele distributions of SNPs in TF pathway genes in cases and controls

Gene	Chr	SNP	Bp (hg18)	Region	Minor allele	Major allele	Freqency cases	Frequency controls	χ 2	OR	P-value (unadj.)	FDR
F2	11	rs2070852	46701501	Intronic	C	G	0.290	0.316	0.99	0.89	0.319	0.83
F2	11	rs3136516	46717332	Intronic	G	A	0.448	0.448	0.00	1.00	0.996	1.00
F2	11	rs5896	46701579	Coding (T > M)	T	C	0.133	0.127	0.09	1.05	0.760	0.93
F2	11	rs1799963	46717631	3UTR	A	G	0.013	0.005	2.20	2.60	0.138	0.61
F3	1	rs3917643	94774455	Intronic	C	T	0.058	0.080	2.58	0.70	0.109	0.57
F3	1	rs696619	94777808	Intronic	A	G	0.414	0.440	0.87	0.90	0.351	0.83
F3	1	rs1324214	94769876	Intronic	A	G	0.240	0.271	1.59	0.85	0.207	0.70
F3	1	rs3917615	94774578	Intronic	T	C	0.439	0.433	0.04	1.02	0.839	0.93
F5	1	rs12120605	167789178	Intronic	T*	G	0.140	0.100	4.93	1.47	0.026	0.22
F5	1	rs6427202	167795454	Intronic	C*	T	0.454	0.394	4.82	1.28	0.028	0.22
F5	1	rs9332542	167805907	Intronic	A	G*	0.286	0.344	5.16	0.76	0.023	0.22
F5	1	rs6427199	167790161	Intronic	A	G*	0.364	0.420	4.36	0.79	0.037	0.23
F5	1	rs6012	167795204	Intronic	T	C	0.162	0.164	0.01	0.98	0.906	0.93
F5	1	rs4524	167778379	Coding (K > R)	C	T	0.261	0.257	0.03	1.02	0.871	0.93
F5	1	rs4656687	167771782	Intronic	C	T	0.323	0.312	0.17	1.05	0.676	0.93
F5	1	rs6025	167785673	Coding (Q > R)	T	C	0.033	0.034	0.02	0.96	0.900	0.93
F5	1	rs9287095	167805090	Intronic	A	G	0.094	0.104	0.34	0.90	0.561	0.93
F5	1	rs10158595	167786988	Intronic	T	C	0.223	0.248	1.14	0.87	0.286	0.83
F5	1	rs9332618	167767105	Intronic	A	G	0.133	0.139	0.08	0.95	0.773	0.93
F7	13	rs491098	112817347	Intronic	C	G	0.106	0.117	0.39	0.90	0.530	0.93
F10	13	rs3093261	112824083	Near 5UTR	T*	C	0.460	0.391	6.41	1.33	0.011	0.22
F10	13	rs3211744	112832999	Intronic	T	G	0.136	0.154	0.85	0.87	0.358	0.83
F10	13	rs2026160	112840894	Intronic	C	A	0.284	0.258	1.08	1.14	0.298	0.83
F10	13	rs9549675	112846885	Intronic	T	C	0.205	0.239	2.10	0.83	0.148	0.61
F10	13	rs3211719	112825510	Intronic	G	A	0.252	0.245	0.09	1.04	0.769	0.93
F10	13	rs3211752	112835460	Intronic	G	A	0.499	0.489	0.13	1.04	0.716	0.93
F10	13	rs556694	112828042	Intronic	C	T	0.093	0.089	0.04	1.04	0.836	0.93
F10	13	rs3211770	112841850	Intronic	A	G	0.109	0.113	0.05	0.96	0.818	0.93
F10	13	rs473598	112849190	Intronic	A	G	0.128	0.137	0.23	0.92	0.629	0.93
EPCR	20	rs2069948	33226150	Intronic	C*	T	0.468	0.408	4.72	1.27	0.030	0.22
TFPI	2	rs2192825	188099064	Intronic	C	T	0.439	0.402	1.81	1.16	0.178	0.66
TFPI	2	rs7594359	188117093	Intronic	T	C	0.461	0.441	0.52	1.08	0.472	0.93
TFPI	2	rs2192824	188077036	Intronic	T	C	0.449	0.428	0.54	1.09	0.461	0.93
TFPI	2	rs13424790	188032097	Downstream	G	T	0.317	0.310	0.08	1.03	0.778	0.93
TFPI	2	rs8176548	188048580	Intronic	T	C	0.351	0.347	0.02	1.02	0.878	0.93
TFPI	2	rs10187622	188122406	Intronic	T	C	0.161	0.165	0.03	0.97	0.864	0.93
TFPI	2	rs12613071	188096556	Intronic	C	T	0.202	0.195	0.09	1.04	0.762	0.93

P-values were determined by the χ² -test. Alleles for the positive DNA strand (UCSC annotated) are shown. Significantly associated SNPs; bold, and factor V Leiden (F5 rs6025) and prothrombin G20210A (F2 rs1799963); italic. *Risk alleles for significant SNPs.

Chr: chromosome. OR: Odds ratio as determined for the minor allele with the major allele as reference. FDR: False discovery rate as described by Benjamini and Hochberg [28].