Table 3.

Distribution of cases and controls among the high or low level categories of the hemostatic parameters

Hemostatic parameter	Cases (n)	Controls (n)	OR	95% CI	P-value
Coagulation activity:
ETP (%)*
<90th percentile	309	246	Ref.	Ref.	Ref.
>90th percentile	37	27	1.09	0.65-1.84	0.744
Lag time (%)*
>10th percentile	211	246	Ref.	Ref.	Ref.
<10th percentile	135	27	5.83	3.71-9.16	<0.001
ttPeak (%)*
>10th percentile	206	249	Ref.	Ref.	Ref.
<10th percentile	140	24	7.05	4.40-11.29	<0.001
Peak (%)*
<90th percentile	208	246	Ref.	Ref.	Ref.
>90thpercentile	138	27	6.05	3.85-9.50	<0.001
APC resistance (nAPC-sr)
FV Leiden non-carriers
<90th percentile	190	228	Ref.	Ref.	Ref.
>90th percentile	135	25	6.48	4.06-10.35	<0.001
FV Leiden carriers
<90th percentile	4	18	Ref.	Ref.	Ref.
>90th percentile	17	2	38.3	6.2-236.6	<0.001
D-dimer (ng/mL)
<90th percentile	292	246	Ref.	Ref.	Ref.
>90th percentile	65	27	2.03	1.26-3.28	0.004
Coagulation inhibitors:
AT (%)
>10th percentile	215	246	Ref.	Ref.	Ref.
<10th percentile	135	27	5.72	3.64-8.99	<0.001
Protein C (%)
>10th percentile	310	246	Ref.	Ref.	Ref.
<10th percentile	40	27	1.18	0.702-1.97	0.539
Protein S (%)
>10th percentile	325	246	Ref.	Ref.	Ref.
<10th percentile	22	27	0.62	0.34-1.11	0.106
Free TFPI (ng/mL)
>10th percentile	319	246	Ref.	Ref.	Ref.
<10th percentile	39	27	1.11	0.66-1.87	0.683

ORs, 95% CI and P-values were obtained by logistic regression with respect to cases.

AT = antithrombin. ttpETP = time to thrombin peak. nAPC-sr = normalised APC sensitivity ratio. (%) describes activity as compared to pooled normal plasma (PNP). *CAT-assay variables.