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. 2014 Nov 10;32(35):3989–3995. doi: 10.1200/JCO.2014.56.8220

Table A1.

Association Between Smoking Status and Cigarettes Smoked per Day and Risk of a Second Primary Smoking-Associated Cancer Among Survivors of Lung (stage I), Bladder, Kidney, and Head/Neck Cancers, Including Follow-Up Time and Event Occurring Within 30 Days of Diagnosis

Smoking Status Stage I Lung
Bladder
Kidney
Head/Neck Cancer
HR 95% CI HR 95% CI HR 95% CI HR 95% CI
Never 1.00 Referent 1.00 Referent 1.00 Referent 1.00 Referent
Former
    < 20 cig/d 0.56 0.17 to 1.88 1.94 1.25 to 2.99 1.95 1.11 to 3.42 1.63 0.91 to 2.91
    ≥ 20 cig/d* 1.09 0.39 to 3.05 2.22 1.45 to 3.40 3.86 2.24 to 6.65 3.08 1.81 to 5.25
Current
    < 20 cig/d 2.05 0.75 to 5.89 2.12 1.96 to 4.95 3.45 1.75 to 6.78 2.90 1.65 to 5.09
    ≥ 20 cig/d* 2.08 0.73 to 5.59 4.10 2.54 to 6.62 5.01 2.49 to 10.1 4.84 2.80 to 8.36
P trend .04 < .001 .001 < .001

NOTE. Adjusted for age, sex, race, education, body mass index, cohort, time from baseline to first cancer, and follow-up time. Excludes Alpha-Tocopherol, Beta-Carotene Cancer Prevention study, given that this cohort was limited to current smokers.

Abbreviations: cig/d, cigarettes per day; HR, hazard ratio.

*

Cigarettes per day was collected as a categorical variable in National Institutes of Health–AARP Diet and Health Study; Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; and Agricultural Health Study. The maximum number of cigarettes smoked per day in the Iowa Women's Health Study was as follows: lung (stage I): 60; bladder: 40; kidney: 40; head and neck: 40.

P trends across joint categories of smoking status and intensity categories were estimated by including the categorical exposure variable in the model as a continuous variable.