Table A5.
Association Between Smoking Status and Risk of a First Primary Smoking-Associated Cancer
| Smoking Status | Cancer Case |
HR | 95% CI | |
|---|---|---|---|---|
| No | Yes | |||
| Never | 307,651 | 11,052 | 1.00 | Referent |
| Former | ||||
| < 20 cig/d | 190,400 | 11,025 | 1.49 | 1.45 to 1.53 |
| ≥ 20 cig/d | 126,965 | 12,175 | 2.35 | 2.29 to 2.42 |
| Current | ||||
| < 20 cig/d | 54,956 | 6,859 | 3.72 | 3.60 to 3.83 |
| ≥ 20 cig/d | 27,797 | 4,957 | 5.41 | 5.22 to 5.60 |
| P trend* | < .001 | |||
NOTE. Adjusted for age, sex, race, education, body mass index, cohort, time from baseline to first cancer, and follow-up time. Excludes Alpha-Tocopherol, Beta-Carotene Cancer Prevention study, as this cohort was limited to current smokers.
Abbreviations: cig/d, cigarettes per day; HR, hazard ratio.
*
P trends across joint categories of smoking status and intensity categories were estimated by including the categorical exposure variable in the model as a continuous variable.