Table 2. Summary of subgroup analysis based on baseline prognostic factors.

Patients	OS			TTP
	HR	95%CI	P value	HR	95%CI	P value
All	0.74	0.61–0.90	0.002	0.69	0.55–0.86	0.001
HBV-positive	0.91	0.76–1.08	0.267	0.74	0.48–1.14	0.174
HBV-negative	0.86	0.44–1.78	0.732	—	—	—
HCV-positive	0.83	0.32–2.15	0.695	—	—	—
ECOG PS 0	0.81	0.59–1.11	0.193	0.64	0.35–1.18	0.000
ECOG PS 1-2	0.77	0.60–1.00	0.050	0.58	0.44–0.75	0.000
MVI and/or EHS present	0.65	0.46–0.93	0.016	0.44	0.28–0.69	0.000
MVI or EHS absent	0.69	0.46–1.05	0.085	0.62	0.50–0.77	0.000
Normal AFP	0.90	0.48–1.71	0.757	—	—	—
Elevated AFP	0.84	0.54–1.32	0.449	—	—	—

OS, overall survival; TTP, time to progression; HR, hazard ratio; ECOG PS, Eastern Cooperative Oncology Group performance status; BCLC, Barcelona Clinic Liver Cancer; MVI, macroscopic vascular invasion; EHS, extrahepatic spread; HBV, hepatitis B virus; HCV, hepatitis C virus

These pooled results were calculated from the included studies of reference of 9,10,32,33.