Table 1.
Principal results obtained with BoHV-1 and BoHV-5 gD vaccines
| Vaccine | Virus | Expression | Adjuvant | Route | Immune Resp. | Protection | Ref. | |
|---|---|---|---|---|---|---|---|---|
| system | Humoral | Cellular | ||||||
| Subunit | BoHV-1 | Native gD | Avridine | i.m. | ++++ | n/a | xxxx | [60,61] |
| BoHV-1 | E. coli | Avridine | i.m. | ++ | n/a | xx | [62] | |
| BoHV-1 | P. pastoris | Oil | i.m. | ++++ | ++ | n/a | [63,64] | |
| BoHV-5 | P. pastoris | Oil | i.m. | ++++ | ++ | n/a | [25] | |
| BoHV-1 | MDBK | Oil | i.m. | ++++ | ++ | xx | [69,70] | |
| BoHV-1 | MDBK | CpG; Alum | i.m. | ++++ | ++++ | xxxx | [71] | |
| BoHV-1 | MDBK | CpG; Oil | s.c. | ++++ | ++++ | xxxx | [72] | |
| BoHV-1 | Plant cellsa | Oil | i.p., s.c, i.m. | n/a | n/a | xx | [66] | |
| DNA | BoHV-1 | pRSV | n/a | i.m. | ++++ | n/a | xx | [79] |
| BoHV-1 | HCMV | n/a | i.d. | ++++ | ++++ | xxxx | [80] | |
| BoHV-1 | HCMV | n/a | i.m. | ++++ | ++++ | xxxx | [82] | |
| BoHV-1 | HCMV | CpG | i.d. | ++ | ++++ | xx | [83] | |
| Vectored | BoHV-1 | BAV-3 | n/a | i.n | ++ | ++++ | xx | [87,88] |
| BoHV-1 | HAd5 | n/a | i.n | ++ | n/a | xxxx | [89,90] | |
a = achieved with a Tobacco Mosaic Virus (TMV)-based vector.
++ = Weak neutralizing antibodies or cell-mediate response.
++++ = Strong neutralizing antibodies or cell-mediate response.
n/a = Data not available.
xx = Partial protection.
xxxx = Total protection.