Table 2.
Clinical characteristics and cell-staining characteristics of patients whose CTCs were evaluated by ImageStreamX
| Patient ID | Prior therapies* | PSA (ng/mL) | EpCAM + Events | CTCs (%) | Mean AR intensity # (STDev) | Median AR intensity # (Range) | AR-high CTCs (%) | Mean SI (STDev) | Median SI (Range) |
|---|---|---|---|---|---|---|---|---|---|
| 12077 | L, B | 168.4 | 5 | 4 (80) | 117262 (120651) | 89033 (29879–322996) | 5 (100) | 0.67 (1.67) | −0.09 (−0.43-3.55) |
| 12076 | L, B, K, A | 41.16 | 115 | 114 (99) | 337937 (286897) | 253104 (−6509-1427349) | 108 (94) | −0.12 (0.85) | −0.25 (−1.79-2.31) |
| 12079 | L, B, S | 32.24 | 104 | 96 (92) | 25456 (36815) | 11486 (1096–193627) | 63 (61) | 0.72 (1.06) | 0.57 (−0.78-4.27) |
| 12078 | L, B, K | 11.12 | 33 | 27 (82) | 3202 (12736) | 216 (−9849-56081) | 5 (15) | 0.97 (1.21) | 0.95 (−0.98-2.06) |
| 12080 | L, B, D, C, A, E | 554 | 0 | NA | NA | NA | NA | NA | NA |
| 12081 | L, D, C | 275.4 | 36 | 24 (67) | 33078 (58419) | 4115 (−12080-240098) | 16 (44) | −0.05 (1.51) | −0.44 (−1.77-3.79) |
| 12082 | B, S | 5.78 | 18 | 11 (61) | 59487 (213913) | 1437 (−6856-913784) | 6 (33) | 0.39 (0.94) | 0.21 (−0.62-1.64) |
| 12083 | L, B, A, E | 522.3 | 12 | 11 (92) | 38260 (29857) | 30748 (3725–92097) | 9 (75) | 0.3 (1.11) | −0.21 (−0.98-2.39) |
| 12084 | L | 164.1 | 24 | 16 (67) | 78782 (214426) | 795 (−5122-800180) | 8 (33) | 0.6 (1.6) | 0.17 (−1.02-3.63) |
| 12081 | L, D, C | 382.6 | 15 | 5 (33) | −2323 (4049) | −2592 (−10466-4384) | 0 | NA | NA |
| 12079 | L, B, S | 39.3 | 0 | NA | NA | NA | NA | NA | NA |
| 12086 | B, L, K, D, A, E, Sa | 1152 | 121 | 116 (96) | 5674 (17971) | 4256 (−13238-182505) | 13 (11) | 0.39 (0.66) | 0.6 (−0.93-1.13) |
| 12087 | L, B | 20.35 | 35 | 35 (100) | −11351 (21968) | −7673 (−68443-33422) | 4 (11) | −0.46 (0.63) | −0.31 (−1.33-0.12) |
| 12086 | B, L, K, D, A, E, Sa | 1320 | 11 | 11 (100) | 115581 (88954) | 102918 (46540–360131) | 11 (100) | −0.36 (0.44) | −0.45 (−0.9-0.64) |
| 12088 | L, B, D | 0.06 | 21 | 18 (86) | 254074 (980505) | 3184 (−1368-4502881) | 4 (19) | −0.2 (2.65) | 0.99 (−4.17-1.38) |
| 12028-101 | L, B, D, A, E | 37.23 | 50 | 48 (96) | 241547 (1561372) | 4910 (−3059-11054469) | 12 (24) | 0.58 (1.51) | 0.35 (−1.88-3.73) |
| 12064-102 | L, B, K, A, C | 6.33 | 4 | 3 (75) | 55055 (63046) | 44257 (1328–130379) | 2 (50) | 3.74 (0.35) | 3.74 (3.49-3.99) |
| 12072-103 | B, L, A, D | 20.59 | 220 | 215 (98) | 21851 (48606) | 7965 (−45736-465037) | 92 (42) | −0.1 (0.64) | −0.17 (−1.2-2.06) |
| 12080-104 | L, B, D, C, A, E | 1040 | 3 | 2 (67) | 81694 (72851) | 108774 (−819-137127) | 2 (67) | 2.36 (0.43) | 2.36 (2.06-2.67) |
| 14093 | Ci/Et, To, Et/Te | 1.83 | 7 | 6 (86) | 5566 (12133) | 2578 (−8042-29243) | 2 (29) | −0.12 (0.36) | −0.12 (−0.38-0.13) |
| 12027-105 | L, B, N, K, D/Da, A, E, R | 489.8 | 40 | 40 (100) | 7995 (31246) | 3127 (−62338-124132) | 5 (13) | 1.32 (0.87) | 1.65 (0.3-2.34) |
| 14093 | Ci/Et, To, Et/Te | 1.98 | 23 | 22 (96) | 500281 (2345906) | 3774 (−9141-11261273) | 8 (35) | −0.33 (1.54) | 0.06 (−3.94-1.17) |
| 12064-102 | L, B, K, A, C | 6.84 | 411 | 408 (99) | 11281 (21967) | 7020 (−6031-267789) | 115 (28) | 0.74 (0.52) | 0.8 (−0.75-1.82) |
| 12072-103 | B, L, A, D | 25.8 | 30 | 30 (100) | 12437 (37826) | 4871 (−19268-203291) | 8 (27) | 0.34 (0.68) | 0.19 (−0.29-1.78) |
| 12088 | L, B, D | 0.06 | 100 | 99 (99) | 5505 (15912) | 1670 (−13453-118622) | 13 (13) | 0.01 (0.61) | −0.17 (−0.89-1.3) |
| 14092 | L, B, K, N, A, R | 498.7 | 13 | 11 (85) | 51770 (97952) | 689 (−60783-230484) | 5 (38) | 1.86 (0.82) | 2.03 (0.48-2.6) |
| 12028-101 | L, B, D, A, E | 46.31 | 29 | 27 (93) | 23411 (69628) | 4050 (−5317-359215) | 7 (24) | 0.92 (1.22) | 0.37 (−0.62-2.85) |
| 12076-106 | L, B, K, A, D | 9.33 | 59 | 59 (100) | 29569 (74779) | 9686 (−24144-356079) | 29 (49) | 1.09 (0.65) | 1.05 (−0.11-3.43) |
| 14090 | L, B, N, S, A | 6.81 | 10 | 8 (80) | 41168 (90507) | −4692 (−83596-201844) | 4 (40) | 2.38 (0.52) | 2.38 (1.76-3.02) |
| 14089 | L, B | 5.06 | 11 | 9 (82) | 192342 (687361) | −2246 (−149355-2254943) | 3 (27) | 2.33 (1.29) | 1.71 (1.47-3.82) |
| 14089 | L, B | 5.87 | 8 | 2 (25) | 1953000 (5025861) | 218121 (−25632-14383254) | 6 (75) | 1.02 (1.71) | 1.53 (−2.35-2.49) |
Thirty-one blood draws from 20 patients were evaluated by ImageStreamX technology, of which 29 blood draws from 20 patients had CTCs identified. SI = similarity index.
*Prior therapies: A = abiraterone, B = bicalutamide, C = cabazitaxel, Ci = cisplatin, D = docetaxel, Da = dasatinib, E = enzalutamide, Et = etoposide, K = ketoconazole, L = LHRH agonist, N = nilutamide, R = radium223, S = sipuleucel-T, Sa = samarium, Te = temozolemide, To = topotecan.
#Negative values are due to compensation within ImageStreamX.