Extended Data Table 4. Reduced Major Axis regression analyses between talonid height and talonid cusp numbers and complexity.

Talonid tabulations include all the posterior cusps. Explants with EDA include only Eda null teeth cultured with EDA protein (2.5 ng/mm to 1000 ng/ml). Values for carnivoran families are based on the means of species for each family (n = 9). For details, see text and methods.

Data	Slope (95% CI)	Intercept (95% CI)	r2	p
Experiments	3.30 (1.76–4.01)	−0.79 (−1.39–0.56)	0.891	0.0003
Experiments (explants with EDA)	4.22 (3.08–5.07)	−1.63 (−2.38– −0.67)	0.946	0.0005
Line from Tribosphenomys to Mus	4.00	−1.00
Carnivoran species (cusps)	6.53 (4.60–7.73)	−1.38 (−2.02– −0.28)	0.594	0.0001
Carnivoran families (cusps)	6.63 (4.68–7.84)	−1.28 (−2.09– −0.07)	0.874	0.0002
Carnivoran species (OPC)	48.24 (33.37–56.50)	−10.93 (−15.64– −2.04)	0.562	0.0001
Carnivoran families (OPC)	50.83 (26.74–62.61)	−12.14 (−20.62–1.64)	0.812	0.0011