Table 3.

Hearing impairment risk of inflammatory mediators related SNPs analyzed using logistic regression with generalized estimating equations

Gene	rs No	Crude: model 1			Adjusted: model 2			Adjusted: model 3
		Odds ration	95% CI	p value	Odds ration	95% CI	p value	Odds ration	95% CI	p value
TNF-α	rs1800630
	Hearing impairment criteria
	PTABE 1)>25 dB	1.120	0.979-1.281	0.100	1.192	1.020-1.392	0.027	1.172	1.005-1.367	0.044
	PTABE 40 dB	1.090	0.885-1.344	0.417	1.109	0.884-1.390	0.372	1.106	0.884-1.384	0.380
TNFRSF1B	rs1061624
	PTABE >25 dB	1.151	1.021-1.297	0.022	1.210	1.052-1.393	0.008	1.211	1.053-1.392	0.007
	PTABE >40 dB	1.272	1.052-1.538	0.013	1.293	1.045-1.599	0.018	1.275	1.026-1.584	0.028
IL1A	rs1800587
	PTABE >25 dB	1.093	0.894-1.335	0.386	1.061	0.845-1.331	0.611	1.070	0.855-1.339	0.557
	PTABE >40 dB	0.975	0.692-1.373	0.885	0.946	0.660-1.354	0.760	0.956	0.667-1.371	0.807
IL1B	rs16944
	PTABE >25 dB	0.941	0.834-1.060	0.316	0.915	0.796-1.052	0.212	0.920	0.801-1.057	0.238
	PTABE >40 dB	0.924	0.762-1.121	0.422	0.960	0.774-1.190	0.706	0.945	0.760-1.174	0.608
IL-4	Rrs1801275
	PTABE >25 dB	0.986	0.829-172	0.872	1.038	0.851-1.265	0.715	1.031	0.847-1.255	0.761
	PTABE >40 dB	0.968	0.729-1.85	0.822	1.010	0.746-1.367	0.949	1.050	0.774-1.424	0.756
IL-6	rs1800796
	PTABE >25 dB	1.011	0.881-1.161	0.872	1.083	0.924-1.269	0.327	1.079	0.922-1.262	0.343
	PTABE >40 dB	1.034	0.829-1.289	0.770	1.042	0.822-1.320	0.734	1.056	0.833-1.339	0.651
IL-10	rs1800872
	PTABE >25 dB	0.981	0.864-1.114	0.764	0.983	0.844-1.145	0.826	0.973	0.838-1.131	0.725
	PTABE >40 dB	0.887	0.714-1.102	0.280	0.860	0.572-1.101	0.231	0.834	0.651-1.070	0.153
IRAK-1	rs1059702
	PTABE >25 dB	1.026	0.912-1.55	0.666	1.012	0.889-1.151	0.862	1.010	0.888-1.148	0.885
	PTABE >40 dB	0.887	0.718-1.097	0.268	0.8161	0.707-1.051	0.141	0.869	0.713-1.058	0.162
CRP2	rs1130864
	PTABE >25 dB	0.976	0.758-1.257	0.81	1.099	0.816-1.479	0.535	1.092	0.817-1.461	0.552
	PTABE >40 dB	0.924	0.624-1.363	0.692	1.081	0.711-1.643	0.715	1.113	0.726-1.705	0.623

¹⁾PTABE : pure-tone average threshold at 0.5, 1, 2 and 4 kHz for the better ear.

Moderating variables.

model 1 : No variables.

model 2 : Age and sex.

model 3 : Any history of noise exposure, ear disease, hypertension, diabetes, dyslipidemia, stroke and cardiac disease, and lifetime smoking habit in addition to those of model 2.