Figure 1. Comparison of brown adipose tissue (BAT) ¹⁸F-FDG uptake in the normal, obese, and diabetes mellitus (DM) mice and their response to BRL37344 intervention.

A: Typical ¹⁸F-FDG microPET images of normal, obese, and DM mice after cold stimulation by steping on ice for 1 h. Arrows showed that the interscapular BAT uptake of ¹⁸F-FDG was decreased in the obese and DM mice. B: Semi-quantitative analysis of BAT-to-liver ratio (BAT/L) of ¹⁸F-FDG uptake showed that the BAT/L was significanly lower in the obese mice (P = 0.036) and further decreased in the DM mice (P<0.001). C: Two-week BRL37344 intervetion (three times per week) significantly increased the BAT/L in the obese mice (P = 0.010) and DM mice (P = 0.004) compared to the corresponding controls. D: Single-dose BRL37344 intervention also significantly increased the BAT/L in the normal mice (P = 0.002).