Figure 10. Cone survival in the predetermined fixed-size circular areas examined after treatment with topical Brimonidine or intravitreal BDNF, PEDF, bFGF or CNTF.

Representative examples of the predetermined-fixed-size circular areas (PCA) analysed in the experimental eyes 7 days after blue-light emitting diode induced phototoxiticy (exposure parameters were 10 secs and 200 Lux) and treatment with topical Brimonidine (1%) or intravitreal BDNF (5 µg), PEDF (2 µg), CNTF (0.4 µg) or bFGF (1 µg), and the corresponding vehicle solutions. For each experimental and its fellow retina, a PCA (3.14 mm² for L- and 5.3 mm² for S-cones) was superimposed on the centre of the lesion and L- or S-cones were counted. Every cone is represented by a white dot. Lower bottom of each area shows the total number of cones counted. Note that the numbers of cones are greater in the BMD, BDNF, PEDF, bFGF treated group than in the corresponding Vehicle-treated groups, but not for the CNTF-treated group.