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. 2014 Dec 2;9(12):e113956. doi: 10.1371/journal.pone.0113956

Figure 7. Comparison of F-5 with becaplermin gel in promoting diabetic pig wound healing.

Figure 7

(A) Images of 1.5 cm×1.5 cm full thickness wounds in triplicates in pigs 45 days following STZ injection were topically treated with increasing amounts of recombinant F-5 protein once on day 0. Wound closure was measured on day 7 and day 14. (B) Quantitative analysis of the wound closure data revealed an optimal concentration for F-5 between 30 µM to 45 µM. * p≤0.05 and ** p≤0.01, compared with placebo. (C) Images of similar wounds were topically treated with 45 µM of F-5 protein or becaplermin gel as prescribed in triplicate on day 0. Wound closure was compared on day 7 and day 14. (D) Quantitative analysis of F-5- and becaplermin gel- stimulated wound closure data. * p≤0.05, p≤0.01 and *** p≤0.001, compared with placebo.