Figure 4. Orally administered KPT-330 attenuated tumor growth.
5×105 ACHN cells were subcutaneously injected to flank region. Once the tumors were palpable, the mice were treated with vehicle, sunitinib (40 mg/kg), KPT-330 low (7.5 mg/kg), KPT-330 high (15 mg/kg) or sunitinib and KPT-330 low for 25 days as discussed in Materials and Methods. Tumor growth was monitored by caliper (tumor volume = length x width x width/2) and tumor growth rate (tumor volume at day X/tumor volume at day 0) was calculated. *P<0.05 compared to control. Error bars indicate standard error.