Table 2. Association between iron supplementation and all-cause mortality and cardiovascular or sepsis-related mortality using time-dependent Cox proportional hazards models*.
| All-cause mortality | CV or sepsis mortality** | |||||
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| Age (years) | 1.05 | (1.03–1.08) | <0.001 | 1.04 | (1.02–1.07) | <0.001 |
| Sex | ||||||
| Female | Ref. | Ref. | ||||
| Male | 1.14 | (0.68–1.90) | 0.6 | 1.38 | (0.73–2.60) | 0.3 |
| Type of renal replacement therapy | ||||||
| Hemodialysis | Ref. | Ref. | ||||
| Peritoneal dialysis | 0.28 | (0.07–1.03) | 0.06 | 0.55 | (0.14–2.12) | 0.4 |
| Transplantation | 0.47 | (0.14–1.54) | 0.2 | 0.38 | (0.08–1.72) | 0.2 |
| Diabetes mellitus | ||||||
| No | Ref. | Ref. | ||||
| Yes | 1.31 | (0.81–2.12) | 0.3 | 1.54 | (0.87–2.73) | 0.1 |
| Iron supplementation | ||||||
| No | Ref. | Ref. | ||||
| Yes | 0.22 | (0.08–0.58) | 0.002 | 0.31 | (0.09–1.04) | 0.06 |
| C-reactive protein (mg/dL) | 1.13 | (1.10–1.17) | <0.001 | 1.11 | (1.07–1.15) | <0.001 |
| Albumin (g/dL) | 0.33 | (0.21–0.50) | <0.001 | 0.31 | (0.18–0.53) | <0.001 |
| Hemoglobin (g/dL) | 0.95 | (0.81–1.12) | 0.5 | 0.90 | (0.75–1.08) | 0.3 |
* Adjusted for age, sex, diabetes mellitus and the time-dependent variables type of renal replacement therapy, C-reactive protein, albumin and hemoglobin.
** Cardiovascular or sepsis mortality: myocardial infarction (MI), heart failure, sudden death, ischemic stroke, hemorrhagic stroke, sepsis.