Table 3. Association between iron supplementation and all-cause mortality in patients with diabetes mellitus and without diabetes mellitus using time-dependent Cox proportional hazards models*.
All-cause mortality | ||||||
Diabetes | Non-Diabetes | |||||
HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
Age (years) | 1.03 | (0.99–1.07) | 0.2 | 1.07 | (1.03–1.10) | <0.001 |
Sex | ||||||
Female | Ref. | Ref. | ||||
Male | 0.98 | (0.45–2.11) | 0.9 | 1.08 | (0.51–2.31) | 0.8 |
Type of renal replacement therapy | ||||||
Hemodialysis | Ref. | Ref. | ||||
Peritoneal dialysis | 0.76 | (0.07–8.73) | 0.8 | 0.30 | (0.08–1.15) | 0.08 |
Transplantation | - | - | - | 0.63 | (0.14–2.82) | 0.5 |
Iron supplementation | ||||||
No | Ref. | Ref. | ||||
Yes | 0.51 | (0.02–1.59) | 0.7 | 0.19 | (0.06–0.56) | 0.002 |
C-reactive protein (mg/dL) | 1.09 | (1.04–1.14) | 0.001 | 1.17 | (1.12–1.22) | <0.001 |
Albumin (g/dL) | 0.24 | (0.11–0.49) | <0.001 | 0.40 | (0.22–0.71) | 0.002 |
Hemoglobin (g/dL) | 0.79 | (0.63–0.97) | 0.03 | 1.09 | (0.89–1.35) | 0.4 |
* Adjusted for age, sex and the time-dependent variables type of renal replacement therapy, C-reactive protein, albumin and hemoglobin.