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. 2014 Dec 2;9(12):e114144. doi: 10.1371/journal.pone.0114144

Table 3. Association between iron supplementation and all-cause mortality in patients with diabetes mellitus and without diabetes mellitus using time-dependent Cox proportional hazards models*.

All-cause mortality
Diabetes Non-Diabetes
HR (95% CI) P-value HR (95% CI) P-value
Age (years) 1.03 (0.99–1.07) 0.2 1.07 (1.03–1.10) <0.001
Sex
Female Ref. Ref.
Male 0.98 (0.45–2.11) 0.9 1.08 (0.51–2.31) 0.8
Type of renal replacement therapy
Hemodialysis Ref. Ref.
Peritoneal dialysis 0.76 (0.07–8.73) 0.8 0.30 (0.08–1.15) 0.08
Transplantation - - - 0.63 (0.14–2.82) 0.5
Iron supplementation
No Ref. Ref.
Yes 0.51 (0.02–1.59) 0.7 0.19 (0.06–0.56) 0.002
C-reactive protein (mg/dL) 1.09 (1.04–1.14) 0.001 1.17 (1.12–1.22) <0.001
Albumin (g/dL) 0.24 (0.11–0.49) <0.001 0.40 (0.22–0.71) 0.002
Hemoglobin (g/dL) 0.79 (0.63–0.97) 0.03 1.09 (0.89–1.35) 0.4

* Adjusted for age, sex and the time-dependent variables type of renal replacement therapy, C-reactive protein, albumin and hemoglobin.