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. 2014 Dec 15;76(12):977–983. doi: 10.1016/j.biopsych.2014.04.013

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© 2014 Society of Biological Psychiatry. All rights reserved.

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Validation and cross-tissue replication of the top-ranked differentially methylated probe (cg07080019) via bisulfite pyrosequencing. Infinium HumanMethylation450 BeadChip array (A) and bisulfite-pyrosequencing (B) data for cg07080019 across each discordant twin pair. Methylation levels estimated by pyrosequencing are slightly lower than the array but confirm depression-associated hypermethylation (p = .02). One twin pair (pair 17) was removed from analyses because of failed amplification. (C) Group comparison of DNA methylation at cg07080019 in the postmortem cerebellum samples confirms depression-associated hypermethylation (p = .03). MDD, major depressive disorder; metC%, percentage cytosine methylation.