Table 1. Selected therapeutic regimens of ibrutinib.

Daily dose	Route of administration	Administered on day(s)	Cycle length	Total dose/month	Reference(s)
1.25-12.5 mg/kg	PO	Daily	–	37.5-375 mg	5
1.25-12.5 mg/kg	PO	1 through 28	35 days	35-350 mg/cycle	5
280 mg	PO	Daily	–	8,400 mg	11, 12
420 mga	PO	Daily	–	12,600 mg	8-10, 12-20
560 mga	PO	Daily	–	16,800 mg	10-12, 21-25
840 mg	PO	Daily	–	25,200 mg	8, 9, 19, 20

Note: PO = oral.

^aConforms to dosing information listed in the manufacturer’s labeling