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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Math Biosci. 2014 Jul 8;257:69–79. doi: 10.1016/j.mbs.2014.06.017

Figure 12.

Figure 12

Model variations against data from the wild-type and CFTR knockout mouse secondary saliva [24]. The CFTR knockout mouse model has the CFTR channel deleted. A: CFTR channel conductance is reduced (to 0.15 of base value). Notice how the model [Na+] for the deletion is unable to capture behavior as measured in the CFTR knockout mouse. B: in addition to the CFTR channel reduction performed in A, the ENaC channel conductance is also reduced (to 0.4 of base value), in which case the model is able to reproduce the observed rise in [Na+].