Table 2.

Cognitive Test Domain Results

Pooled Antidepressants vs. Placebo
Cognitive Domain	N Studies	N Participants	Hedges’ g	95% CI	P	I2%
Executive function	8	259	0.17	0.025,0.31	0.02	47
Attention	5	321	0.022	−0.19,0.23	0.84	0
Processing Speed	6	344	0.09	−0.031,−0.21	0.15	16
Visuospatial Processinga	3	94	0.14	−0.73,1.00	0.76	78b
Auditory Verbal Long-Term Memory	4	110	0.058	−0.20,0.31	0.66	41
Visuospatial Long-Term Memorya	4	141	0.07	−0.45,0.59	0.79	66b
Long-Term Memorya	7	214	0.11	−0.18,0.40	0.45	45
Auditory Verbal Working Memory	4	288	0.11	−0.12,0.34	0.34	0
Visuospatial Working Memory	4	123	0.063	−0.18,0.31	0.61	7
Working Memory	8	412	0.074	−0.087,0.24	0.37	0
Auditory Verbal Memory	5	308	0.084	−0.081,0.25	0.32	20
Visuospatial Memorya	5	160	0.065	−0.16,0.29	0.57	0
Memory	9	432	0.077	−0.038,0.19	0.19	46
Verbal Fluency	5	327	0.019	−0.14,0.18	0.81	0
Composite Cognition Score	11	501	0.095	0.021,0.17	0.012	45

Positive Hedges’ g favors treatment group; fixed effects models, except where noted

Bolded p-values: p < 0.05

^aRandom effects

^b< 3 studies available per subgroup so planned subanalyses not run