Table 1.
Characteristics of individuals and eyes at enrollment for individuals in the Longitudinal Study of Ocular Complications of AIDS without cytomegalovirus retinitis.
| Characteristics of patients at enrollment | Participants (N = 1606) |
|
|---|---|---|
| Demographic characteristics | ||
| Age at enrollment, years | ||
| Median (interquartile range) | 43 | (38 , 49) |
| Gender | ||
| Female | 317 | (20%) |
| Male | 1289 | (80%) |
| Race/Ethnicity | ||
| White | 739 | (46%) |
| Black | 577 | (36%) |
| Hispanic | 236 | (15%) |
| Other | 54 | (3%) |
| Education | ||
| High school or less | 652 | (41%) |
| Some college | 490 | (31%) |
| College graduate | 460 | (29%) |
| Missing, N(%) | 4 | (0%) |
| Associated morbidities | ||
| Karnofsky score | ||
| 90–100 | 826 | (52%) |
| ≤ 80 | 779 | (49%) |
| Missing, N(%) | 1 | (0%) |
| Anemia | ||
| No | 1104 | (69%) |
| Yes | 492 | (31%) |
| Missing, N(%) | 10 | (1%) |
| Diabetes | ||
| No | 1462 | (91%) |
| Yes | 144 | (9%) |
| Hypertension | ||
| No | 1282 | (80%) |
| Yes | 323 | (20%) |
| Missing, N(%) | 1 | (0%) |
| Hyperlipidemia | ||
| No | 1256 | (78%) |
| Yes | 346 | (22%) |
| Missing, N(%) | 4 | (0%) |
| Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) History | ||
| Years since AIDS diagnosis (years) | ||
| Median (interquartile range) | 4.2 | (1.6 , 7.1) |
| Absolute CD4+ T cell count, cells/µL | ||
| Median (interquartile range) | 189 | (78 , 338) |
| Cells/uL, N(%) | ||
| ≥ 50 cells/uL | 1306 | (82%) |
| < 50 cells/uL | 283 | (18%) |
| Missing, N(%) | 17 | (1%) |
| Nadir CD4+ T cells (cells/uL) | ||
| ≥ 50 cells/uL | 742 | (47%) |
| < 50 cells/uL | 839 | (53%) |
| Missing, N(%) | 25 | (2%) |
| (HIV) viral load, log10(copies/mL) | ||
| Median (interquartile range) | 2.9 (2.0, 4.7) | |
| Log 10 (copies/mL) | ||
| < 2.6 (undetectable) | 677 | (44%) |
| 2.6 or higher | 848 | (56%) |
| Missing, N(%) | 81 | (5%) |
| Highly active antiretroviral therapy | ||
| No | 261 | (16%) |
| Yes | 1344 | (84%) |
| Missing, N(%) | 1 | (0%) |
| Co-infections | ||
| Cerebral toxoplasmosis | ||
| No | 1593 | (99%) |
| Yes | 13 | (1%) |
| Hepatitis B | ||
| No | 1488 | (93%) |
| Yes | 117 | (7%) |
| Missing, N(%) | 1 | (0%) |
| Hepatitis C | ||
| No | 1487 | (93%) |
| Yes | 118 | (7%) |
| Missing, N(%) | 1 | (0%) |
| Ocular characteristics |
Eyes (E = 3212) |
|
| Anterior inflammation* | ||
| No | 3121 | (97%) |
| Yes | 91 | (3%) |
| Vitreous inflammation† | ||
| No | 3151 | (98%) |
| Yes | 61 | (2%) |
| History of retinal detachment‡ | ||
| No | 3188 | (99%) |
| Yes | 24 | (1%) |
*
Anterior chamber cells or flare, diagnosis with anterior uveitis or keratitis, presence of posterior synechiae, or a combination thereof.
†
Vitreous haze, anterior vitreous cells, intermediate uveitis, endophthalmitis.
‡
Retinal detachment includes individuals with a documented history of retinal detachment and/or the presence of silicone oil.