Table 4.
Enrichment of the White Adipose Tissue reference network (WATRefNet) with different disease-relevant gene sets
| Obesity | ADT all depots | ADT visceral | ADT subcutaneous | ADT gonadal | Drug targets | |
|---|---|---|---|---|---|---|
| Total genes | 47,938 | 47,938 | 47,938 | 47,938 | 47,938 | 47,938 |
| Total disease genes | 103 | 1,208 | 0 | 77 | 1,148 | 54 |
| AdipRefNet genes | 4,194 | 4,194 | 4,194 | 4,194 | 4,194 | 4,194 |
| AdipRefNet disease genes | 70 | 475 | 0 | 35 | 454 | 27 |
| Fisher exact test p value | 2.59E−49 | 1.44E−190 | 1 | 2.02E−17 | 4.55E−183 | 4.60E−15 |
“Total genes” refers to total number of human genes in Entrez gene database. Obesity: Genes linked to MeSH term “Obesity”, ADT: differentially expressed genes in the anti-diabetic treatment study, Drug targets: anti-obesity drug targets from DrugBank