Figure 2. Increased aortic stiffness and altered structural protein expression in old mice; reversal by trehalose.
(A) Aortic pulse wave velocity (aPWV) in young and old control (YC and OC) and young and old trehalose treated (YTre and OTre) mice. Representative Doppler flows at right. (B) Collagen I and elastin protein expression. Representative Western blot images below. Protein expression data presented relative to GAPDH and normalized to YC mean value. Means ± SEM (n = 6–8 per group). *P < 0.05 vs. YC. **P < 0.05 vs. OC