Figure 5. Expression of interferon-induced genes in CD8+ T cells of vaccinated and unvaccinated animals.
With the exception of IFI6 at 20 weeks PV, no statistically significant increases in expression of interferon-induced genes were detected in the peripheral CD8+ T cells of SIVΔnef inoculated animals during the vaccination period or following SIVmac251 challenge. In contrast, interferon-induced genes were strongly up regulated in the CD8+ T cells of unvaccinated controls 3 weeks following SIVmac251 infection. Note: * denotes p-value ≤ 0.05; ** denotes p-value ≤ 0.01.