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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Virology. 2014 Oct 1;0:581–591. doi: 10.1016/j.virol.2014.09.013

Figure 6. Analysis of type I and II interferon signaling factors.

Figure 6

The expression JAK and STAT signaling factors linked to type I and type II IFN signaling in the peripheral CD8+ T cells of SIVΔnef vaccinated animals and unvaccinated controls is shown. JAK2 and STAT2 were modestly up regulated at 40 weeks post-vaccination, and again following SIVmac251 challenge. STAT1 displayed modest induction following SIVmac251 challenge but showed no statistically significant increases during the vaccination period. In contrast, and JAK-STAT signaling molecules were all strongly up regulated in unvaccinated controls 3 weeks following SIVmac251 infection. Note: * denotes p-value ≤ 0.05; ** denotes p-value ≤ 0.01; *** denotes p-value ≤ 0.001.