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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Virology. 2014 Oct 1;0:581–591. doi: 10.1016/j.virol.2014.09.013

Figure 7. SIVΔnef up regulates expression of immunoregulatory molecules.

Figure 7

Increased expression of (A) CD25, (B) CD264, and (C) IL-37 was detected in circulating CD8+ T cells at 3 weeks post-vaccination. Macaques that ultimately displayed protective immunity to SIVmac251 challenge (225-97 and 292-07) displayed the most consistent and often the largest magnitudes of induction at 3 weeks PV, and these changes are highlighted in the graphs by connecting lines. Statistically significant (p value ≤ 0.05) increases in the expression of CTLA4, IL-10, and TGFβ were observed in all vaccinated animals at 20 weeks PV. In contrast, no similar increases were detected in the expression of immunoregulatory molecules in unvaccinated SIVmac251 infected animals. Note: * denotes p-value ≤ 0.05; ** denotes p-value ≤ 0.01.