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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Virology. 2014 Oct 1;0:581–591. doi: 10.1016/j.virol.2014.09.013

Figure 9. Characteristics of systemic CD8+ T cell response in animals with protective immunity to SIVmac251.

Figure 9

(A) A distinct set of cell adhesion molecules, leukocyte immunoglobulin-like receptors, and T cell activation biomarkers was up regulated predominantly in CD8+ T cells from SIVΔnef vaccinated macaques that displayed protective immunity to pathogenic SIVmac251 challenge (225-97 and 292-07). (B) Network diagram of known relationships between biomarkers of T cell activation that were up regulated in macaques 225-97 and 292-07 at 3 weeks PC. The network depicts co-stimulatory interactions and other functional relationships between IL2RG, IL7RA, FOS, LCK, STAT6, and CD69 that were identified utilizing the Ingenuity Pathway Analysis program.