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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: J Neuroimmunol. 2014 Sep 16;276(0):142–149. doi: 10.1016/j.jneuroim.2014.09.006

Figure 5.

Figure 5

Cytokine responses during the late stage of EAE. MNCs from the RORγt Tg mice (open bars) produced significantly more IL-17 (A), IL-10 (B), IL-6 (C), and IFN-γ (D) in response to MOG35-55 compared with wild-type mice (closed bars) (*, P < 0.05, t test). ConA also induced higher production of all cytokines in RORγt Tg mice compared with wild-type mice. MNCs were isolated from the inguinal lymph nodes of wild-type or RORγt Tg mice 2 months p.i. and stimulated with ConA or MOG35-55 for 48 hr. The levels of cytokine production in the culture supernatants were measured by ELISA. The results are representative of 4 experiments, consisting of 7–15 mice, for a total 21 wild-type and 19 RORγt Tg mice. Results are mean + SEM from three pools of inguinal lymph nodes from two mice per pool.