EAE in T-bet Tg mice. Wild-type mice (closed squares) and T-bet Tg (open triangles) mice were sensitized with MOG. T-bet Tg mice did not develop clinical signs (A), spinal cord pathology (B), or substantial immune responses to MOG35-55 (C) 2 months p.i. [*, P < 0.05, compared with wild-type mice, Mann-Whitney U test (A) and t test(C)]. A. Clinical scores of EAE. B. Luxol fast blue staining of the spinal cord. C. Lymphoproliferative responses to MOG35-55. The results are representative of two experiments, consisting of 10-15 mice, for a total of 9 wild-type and 11 T-bet Tg mice. Magnification B: × 28.