Barnes maze was used to assess escape times for control (black symbols, N=32), GR (white symbols, N=25) and GR-leptin mice (gray symbol, N=25). GR mice found the escape hole faster on Day 1 (A, *p=0.02). Relative to baseline, GR mice did not improve their escape times on days 2 and 3 (#p<0.05 versus control) (B). Leptin supplementation normalized the abnormalities seen with GR mice.