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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Biochem Pharmacol. 2014 Aug 30;92(2):389–402. doi: 10.1016/j.bcp.2014.08.025

Fig. 4. MET-related diuretic compounds do not significantly activate the PXR-regulated CYP3A4 promoter.

Fig. 4

(A) HepG2, (B) LS180, and (C) LS174T cells transiently transfected with hPXR, CYP3A4-luc, and CMV-Renilla were treated for 24 h with indicated concentrations of rifampicin or indicated diuretics prior to luciferase assay.