Table 3.
Proteins that were up-regulated or down-regulated by Dietary Calorie Restriction (DCR) versus the Control utilizing a 2D-DlGE gel.a
| Proteins Up-Regulated by DCRb | Proteins Down-Regulated by DCRc |
|---|---|
| 6-phosphogluconolactonase | PDZ and LIM domain protein |
| trisephosphate isomerase | myosin light chain (phosphorytable) |
| kininogen 1 precursor | myosin A2 catalytic light chain |
| albumin | enolase 3: beta muscle |
| ornithine aminotransferase | gelsolin-like capping protein (capG) |
| carbonic anhydrase 3 | carbonic anhydrase 3 |
| apolipoprotein A-1 | ATP Synthase (H+ transporting, F1) |
| heat shock protein (cystallin related) | aldose reductase |
| Flavin reductase (NADPH-dependent) | UGP2 protein |
| peroxiredoxin 6 | phosphoglycerate kinase |
| aconitase 2 | |
| adenylate kinase isoenzyme 1 |
a
Proteins were scanned using a Typhoon 9410 scanner with resolution of 50 µm
b
Up-regulated proteins had fold-change of ≥1.50, p<0.05
c
Down-regulated proteins had fold-change of ≥1.50, p<0.05