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Post-traumatic impairment of glymphatic pathway function promotes tau aggregation. Schematic representation of proposed relationship between perivascular AQP4 polarization, glymphatic pathway function, and interstitial tau clearance after TBI. We propose that chronic loss of perivascular AQP4 polarization after TBI impairs paravascular clearance of interstitial tau, promoting tau aggregation, neurodegeneration, and persistent neuroinflammation in the post-traumatic brain.
