Figure 9.

Removal of NG2 causes increased dieback of sensory fibers after SCI. NG2 may be necessary to prevent further dieback after DCC. a, Dextran-Texas Red (DexTR)-labeled fibers are found within the lesion core of WT mice 14 d after DCC. b, Inset from a, showing where the majority of fibers stabilize in WT mice. c, DexTR-labeled fibers are found more caudal to the lesion in NG2-KO mice littermates. d, Inset from c, showing the majority of fibers in the KO animals are found caudal to the lesion, rather than within the lesion core. e, Quantification of the distance of the fiber front away from the lesion center. Two-sample t test, *p = 0.035, p = 0.302. t₍₄₎ = 3.13, t₍₇₎ = 1.11. Scale bars: a, c,100 μm; b, d,50 μm.