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. 2014 Dec 3;34(49):16385–16396. doi: 10.1523/JNEUROSCI.1135-14.2014

Figure 6.

Figure 6.

Injection of dexmedetomidine into the VLPO increased behavioral arousal. Shown are the number of mice that exhibited signs of behavioral arousal when drugs were injected into the VLPO (n = 10) (A) or >300 μm from the edge of the VLPO (n = 8) (B). Drugs tested in animals anesthetized with 0.8% isoflurane include norepinephrine (NE), dexmedetomidine (Dex), phenylephrine (Phen), and saline. Dexmedetomidine was also injected in animals anesthetized with 1.0% isoflurane (A only). C and D show the fraction of mice that were immobile for a given percentage of the observation period after injection of drugs into the VLPO (C) or >300 μm from the edge of the VLPO (D) in mice anesthetized with 0.8% isoflurane. Data were analyzed by Cox regression.