Figure 9.

Dexmedetomidine in the VLPO increased the amplitude of somatosensory-evoked potentials. A, Graphic representation of the location in the primary barrel cortex (S1B) in which the recording electrode was placed. B, The change in the absolute value of the amplitude of evoked LFPs after injection of dexmedetomidine (red; Dex) or saline (blue) at each recording site throughout the depth of the barrel cortex. The reference electrode is indicated by REF. The electrode at 1100 μm depth was nonfunctional and thus is not shown. A two-way ANOVA indicated a significant effect of drug (p < 0.0001). C, D, Representative traces of the average LFP evoked by a whisker stimulus before and after injection of dexmedetomidine (C) or saline (D) from the electrode at 200 μm depth. Stimulus time is marked by a dotted gray line.