Figure 1.

Effect of Ex-9 on water intake stimulated by hypertonic saline. Rats (n = 11) received a subcutaneous injection of isotonic saline (white bars) or hypertonic saline (black bars), before an LV injection of vehicle or Ex-9. A repeated-measures design was used so that all rats received all four treatment conditions, in balanced order, with at least 4 d between treatments. A, Treatment with Ex-9 increased total water intake during the 2 h test in all rats regardless of saline treatment. B, Treatment with Ex-9 increased the number of licking bursts during the 2 h test. C, Treatment with Ex-9 had no effect on the number of licks per burst. D, An LV injection of vehicle (Veh) did not affect fluid intake in rats given subcutaneous hypertonic saline. Asterisks indicate a main effect of Ex-9 versus vehicle (p < 0.05).