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. 2014 Dec 3;34(49):16482–16495. doi: 10.1523/JNEUROSCI.3418-14.2014

Figure 7.

Figure 7.

Region-specific depletion of PSD-95 with aging in hT-337M mice. A, B, Representative Western blots and quantification of PSD-95 levels in the ventral (VS) and dorsal (DS) striatum of hT-337M mice. B, In the ventral striatum of hT-337M mice, PSD-95 levels were decreased as early as 14 months (n = 11 Ntg, 13 hT-337M) and remained decreased at 22 months in hT-337M mice (n = 15 Ntg, 14 hT-337M). PSD-95 levels were not different in the dorsal striatum even by 22 months. n = 12 Ntg, 10 hT-337M. C, Representative blot and quantification of PSD-95 levels in the ventral striatum of 22-month-old Ntg and hT-WT mice showing no differences. n = 9 Ntg, 10 hT-WT. D, E, Representative Western blots and quantification of PSD-95 levels in the insular cortex and motor cortex of hT-337M mice. E, In the insular cortex of hT-337M mice, PSD-95 levels were decreased as early as 2 months (n = 10 Ntg, 8 hT-337M) and remained decreased at 22 months in hT-337M mice (n = 15 Ntg, 14 hT-337M). PSD-95 levels were not different in the motor cortex even by 22 months (n = 15 Ntg, 14 hT-337M). F, Representative blot and quantification of PSD-95 levels in the insular cortex of 22-month-old Ntg and hT-WT mice showing no differences (n = 9 Ntg, 10 hT-WT). *p < 0.05, **p < 0.01, ***p < 0.001, #p = 0.0938.