Table 1.

Intrinsic membrane properties and ability to fire action potentials were unchanged in the ventral striatum of hT-337M mice

	Ntg	hT-337M	p
Input resistance (MΩ)	132.4 (4.7)	132.3 (6.5)	0.9876
Resting membrane potential (mV)	−80.9 (0.7)	−80.0 (0.6)	0.3797
AP threshold (mV)	−27.4 (1.3)	−27.2 (2.2)	0.9390
AP amplitude (mV)	67.8 (3.3)	66.0 (5.8)	0.7732
AP maximum rate of rise (mV/ms)	105.8 (7.6)	100.3 (10.7)	0.6800
AP half-width (ms)	1.24 (0.06)	1.25 (0.06)	0.8945

Whole-cell current-clamp recordings demonstrated that neurons in the ventral striatum of hT-337M mice have normal membrane excitability and are able to fire normal action potentials in response to current injections (n = 23 neurons in 9 Ntg mice, 11 neurons in 5 hT-337M mice; p value from two-tailed t test for each measurement) AP, Action potential.