Table 2.

General recommendations for use of 4-factor prothrombin complex concentrate for intracranial hemorrhage with warfarin-associated coagulopathy

Any patient suffering from head trauma with an initial or current GCS < 9 (severe TBI) with an abnormal head CT scan (e.g. skull fracture, hydrocephalus, intracranial hemorrhage of any size). Any patient suffering from head trauma with intracranial hemorrhage of any size and initial or current GCS < 13 (moderate or severe TBI). Any patient suffering form intracranial hemorrhage that meets, or is at risk of meeting, criteria for urgent or emergent neurosurgical intervention, regardless of presenting or current GCS. Examples: ○ Acute subdural hematoma ≥ 3 mm in size ○ Epidural hematoma of any size ○ Cerebellar hematoma of any size ○ Cerebral intraparenchymal hematoma or hemorrhagic contusion > 1 cm in diameter in any plane or > 30 cc in volume ○ Fourth ventricle hemorrhage ○ Aneurysmal subarachnoid hemorrhage ○ Multifocal traumatic subarachnoid hemorrhage Any patient scheduled to undergo an emergency neurosurgical procedure within a 4 hour time period.

cc = cubic centimeter, GCS = Glasgow Coma Scale, TBI = traumatic brain injury.