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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Cancer Biol. 2014 Aug 19;0:51–58. doi: 10.1016/j.semcancer.2014.08.003

Figure 1.

Figure 1

The multi-faceted Cripto-1-interacting hub. Cripto-1, in yellow, interacts with various components of multiple signaling pathways to drive processes including stem cell renewal, EMT, proliferation and oncogenesis (green). Inhibitors and cellular components that counteract the oncogenic properties of Cripto-1 are shown in red. Above right, the domains of Cripto-1 are shown with therapeutic interactions. Interactions that are hypothesized, but not yet experimentally shown, are indicated by a “?”. Numbers represent the amino acid numbers at the beginning and end of each domain/region.