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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Exp Cell Res. 2014 Jul 9;329(1):139–147. doi: 10.1016/j.yexcr.2014.07.007

Figure 2.

Figure 2

Model for the role of Mre11 catalytic activities during repair of DSBs in mitotic homology directed repair (left) and meiotic recombination (right) based on studies in budding yeast and mammalian cells (Garcia et al., 2011; Shibata et al., 2014). An Mre11-dependent endonucleolytic cut is made at a distance from DSB. Mre11 exonuclease activity is proposed to process the single-strand break in the 3′ to 5′ direction towards the DSB and other nucleases (for instance Exo1) would continue resection in the 5′-3′ direction away from the DSB.