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. Author manuscript; available in PMC: 2015 Nov 3.
Published in final edited form as: FEBS Lett. 2014 Sep 12;588(21):3878–3885. doi: 10.1016/j.febslet.2014.08.030

Figure 9. CYP51 structure based VNI scaffold development.

Figure 9

A. Structural formulas of VNI and its derivatives VNT and VFV. B. Superimposition of CYP51 complexes with VNT (grey) and VFV (red). The length of the Fe-N coordination bond in each complex is marked respectively. C. Slice through the binding cavity of CYP51 complexes with VNI (cyan) and VFV (red); surface representation. Left: overall structure, distal view. The SRS5 area (the C-terminal portion of helix K – β strand 1–4) is depicted as red ribbon. Right: enlarged view of the active site. The heme is shown as orange spheres.