Table 1.
Sequence variations in CYP51s from different T.cruzi strains*
|
T. cruzi strain |
CYP51 (GenBank Protein ID) |
Amino acids | DNA | ||
|---|---|---|---|---|---|
| % identity | # of differences (amino acid substitutions) | % identity | # of differences | ||
| CL-Brener | A (XP_820210) | 100 | 0 (none) | >99 | 2 (2 silent) |
| B (XP_821219) | 99 | 4 (G9A, D62E, A117S, E160K) | 97 | 35 (31 silent) | |
| Y | A (AFW98339) | 99 | 1 (P355S) | >99 | 3 (2 silent) |
| B (AFW98340) | 99 | 4 (G9A, D62E, A117S, E160K) | 97 | 33 ( 29 silent ) | |
| Colombiana | A (AGF25233) | 98 | 8 (A117S, E160K, H196R, K203Q, V245I, K314E, D405E, P480S) | 98 | 19 (11 silent) |
| B (AGF25234) | 98 | 7 (G9A; L13P, P32S, D62E, A117S, E160K A288S) | 97 | 39 (32silent) | |
| Sylvio | Single, A-like (EKG07251) | 98 | 6 (G9C, A117S, E160K, H196R, V245I, D405E) | ||
| Marinkellei | Single, B-like (EKF39305) | 95 | 24 | ||
*
compared with Tulahuen CYP51